Abul Bashar Ripon Khalipha 1.2*, SM Hafiz Hassan1, Pranta Ray1, Iffat Ara Shaon3, Rajat Bagchi1, Dr.Md. MA Mazid4
1Bangabandhu Sheikh Mujibur Rahman Science & Technology University, Gopalganj, Bangladesh
2Evergreen Scientific Research Centre, Gopalganj-8100, Bangladesh
3 Jahangirnagar University, Savar,Dhakd,Bangladesh
4Department of Pharmacy,University of Dhaka,Bangladesh
Abstract: Epalrestat is a noncompetitive and reversible aldose reductase inhibitor usefulness for the treat of diabetic neuropathy and retinopathy. Molecular docking is a frequently employment tool in computer-aided illegal drug sketch. Structure-supported drug design (SBDD) and ligand-based drug design (LBDD) are the two usual types of computer-aided drug plan (CADD) coming in existence edifice-based rational dope design in pharmaceutical bioinformatics. The objective of the current muse was to perscrutate the worst aldose reductase inhibitor of epalrestat or its halogenated derivatives second- hand in brownian docking muse. Recent years have also seen the trait of rework ligands using halogens and trifluoromethyl (–CF3) group to ensure enhanced dope performance. In this meditation, in silico modification of epalrestat with -Cl,-F,-Br, -I atoms and –CF3 assemblage has been fulfill. -Cl, -Br, -I atoms and –CF3 group has been performed.